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Affected passengers will be rerouted, mainly on Delta's flights out of Johannesburg. The airline describes the suspension as "temporary" due to the current economic crisis resulting in unsatisfactory loads.
However, Sales Director for Africa, the Middle East and India, Jimmy Eichelgruen, said Delta "remains committed to the South African market" and to offering direct service between the US and South Africa.
He added that the airline's route from Johannesburg to Atlanta via Dakar "remained strong" and had not suffered the same decline in loads as the Cape Town service.
Cape Town is not alone. In line with other carriers' schedule reductions, addressing the economic situation, Delta is to reduce its total international schedules by 15 percent.
Delta will continue to offer its daily Johannesburg-Atlanta service and has enhanced the route with the introduction of a Boeing 777-200LR, with 35 additional seats and lie-flat business class seats.