SA Express flights from King Shaka International Airport in Durban to Mozambique, Botswana and Namibia have been given the green light.
The flights could kick off as soon as March next year, SA Express CEO Inati Ntshanga was quoted as saying by IOL.
Rights for air traffic and landings in the Democratic Republic of Congo are also being negotiated, Ntshanga reportedly said.
Maputo is looking set to be the first route to be active, owing to its close proximity to KwaZulu-Natal.
"We need the capacity and aircraft. We also need pilots for the new routes," Ntshanga reportedly said.
"This will reduce flying via Johannesburg – making it quicker for Durban's customers."